I have had this issue several times now and it frustrates me more and more!
I have a working Raspberry Pi 3B+ with a CODESYS USB dongle and a Raspberry Pi SL.
I did a fresh install of Raspbian Buster Lite and ran Raspi-Config to enable SPI, 1 wire, serial COM,i2c and Wireless ETH.
Then I loaded the Raspberry Pi with a fairly new CODESYS runtime (220.127.116.11) + reboot.
When I insert the dongle and start the License Manager (Tools->License manager) and select the runtime, the dongle is not discovered and "System Info"
shows me the message "no runtime license - running in demo mode(~119 minutes)"
It seems USB is not working properly, which is weird because if I plug in the dongle some lights are starting to flash on/off.
ps $dmesg shows the wibu dongle,
$lsusb also shows the dongle.
=> What am I doing wrong?